CLDN16

Across TCGA patient cohorts, CLDN16 protein abundance is significantly associated with the RNA expression of many other genes, with 2,714 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CLDN16-associated genes across cancer lineages are TJP1, INTS9, and SFRP1. Each is linked with CLDN16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN16-to-partner and partner-to-CLDN16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN16 versus TJP1 in OV, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN16→partner) and Y-score (partner→CLDN16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TJP1 →	-0.811	-0.678	.009	.006	3	1
OV	INTS9 →	-0.702	-0.748	.004	.009	3	1
OV	SFRP1 →	-1.433	-0.713	.008	<.001	3	1
OV	SYNGR2 →	+0.825	+0.829	<.001	<.001	3	1
OV	TBC1D30 →	-0.422	-0.781	<.001	<.001	3	1
OV	PCYOX1 →	-0.686	-0.783	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

CLDN16 vs TJP1 — OV

Explore this scatter interactively →