CLDN15

Across TCGA pan-cancer cohorts, CLDN15 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CLDN15 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CLDN15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLDN15 expression acts as an unfavorable survival marker.

LUAD, OV, and UCEC are the cancer types where CLDN15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.223	0.835	<.001	30	view →
OV	DFS	Median	II,III,IV	0.140	0.541	.001	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CLDN15–LUAD (OS)

Open the LUAD breakdown →