CLDN15

Across TCGA patient cohorts, CLDN15 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN15-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with CLDN15 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN15-to-partner and partner-to-CLDN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CLDN15-low versus CLDN15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN15→partner) and Y-score (partner→CLDN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.090	-3.295	.023	.009	3	1
UCEC	eEF2 →	+0.418	+2.459	.002	.018	3	1
UCEC	eIF4E →	+0.249	+3.169	.002	<.001	3	1
UCEC	ERK2 →	+0.244	+2.700	.001	.006	3	1
UCEC	Fibronectin →	-0.282	-2.502	.029	.002	3	1
UCEC	GAPDH →	+0.476	+2.459	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by CLDN15 expression — UCEC

Explore this box plot interactively →