CLDN15

Across TCGA cell cohorts, CLDN15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,561 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLDN15-associated GO terms across cancer lineages are Regulation of intestinal absorption, Pre-mRNA catabolic process, and mRNA splice site recognition. Each is linked with CLDN15 in more than 15 cancer types. Because this analysis shows association rather than direction, both CLDN15-to-partner and partner-to-CLDN15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intestinal absorption grouped by CLDN15-low versus CLDN15-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN15→partner) and Y-score (partner→CLDN15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of intestinal absorption →	+0.282	+1.557	<.001	.001	3	16
BONE	Pre-mRNA catabolic process →	+0.222	+1.241	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.103	+0.832	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.075	+1.174	<.001	<.001	3	12
LIVER	Negative regulation of DNA-templated transcription, elongation →	+0.133	+1.712	<.001	<.001	3	12
KIDNEY	Positive regulation of calcium ion import →	-0.185	-1.391	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,561 associations by consensus.

Regulation of intestinal absorption by CLDN15 expression — STOMACH

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