CLDN10

Across TCGA patient cohorts, CLDN10 mutation is significantly associated with the RNA expression of many other genes, with 2,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN10-associated genes across cancer lineages are CCL5, UHRF1, and RNA5SP411. Each is linked with CLDN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN10-to-partner and partner-to-CLDN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL5 grouped by CLDN10-low versus CLDN10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN10→partner) and Y-score (partner→CLDN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL5 →	+1.107	+3.906	<.001	<.001	3	2
UCEC	UHRF1 →	+0.738	+1.885	<.001	.001	3	2
UCEC	RNA5SP411 →	+0.795	+1.545	<.001	.007	3	2
UCEC	DRD2 →	-0.384	-2.668	.007	.005	3	2
UCEC	FERMT3 →	+0.702	+2.939	<.001	<.001	3	2
COAD	ATP5F1A →	+0.463	+2.740	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,284 associations by consensus.

CCL5 by CLDN10 expression — UCEC

Explore this box plot interactively →