CLDN10

Across TCGA pan-cancer cohorts, CLDN10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CLDN10’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLDN10 RNA is repressed in tumor relative to normal tissue. In most cancer types CLDN10 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where CLDN10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLDN10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−2.357	<.001	12	view →
KICH	Male	IV	−6.743	<.001	11	view →
THCA	Male	III,IV	+4.130	<.001	11	view →
KIRP	All	III,IV	−2.780	<.001	11	view →
HNSC	Male	II,III,IV	−2.547	<.001	11	view →
LUAD	Male	II,III,IV	+3.021	<.001	8	view →
UCEC	All	III,IV	−2.506	.001	6	view →
BRCA	All	III,IV	−1.127	<.001	6	view →
CHOL	All	All	+4.154	<.001	5	view →
LUSC	All	All	+1.213	<.001	5	view →
LIHC	Male	III,IV	−1.103	<.001	4	view →
COAD	All	All	+0.547	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CLDN10–KIRC

Open the KIRC breakdown →