CLDN10

Across TCGA patient cohorts, CLDN10 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN10-associated genes across cancer lineages are Caspase-7-cleavedD198, PEA-15_pS116, and YB-1. Each is linked with CLDN10 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN10-to-partner and partner-to-CLDN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLDN10-low versus CLDN10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN10→partner) and Y-score (partner→CLDN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.775	+3.926	<.001	<.001	3	3
UCEC	PEA-15_pS116 →	+0.278	+1.807	.027	.025	3	2
UCEC	YB-1 →	+0.141	+1.700	.013	.042	3	2
UCEC	14-3-3_beta →	-0.112	-1.912	.001	.005	3	1
UCEC	eEF2 →	+0.401	+1.906	.001	.015	3	1
UCEC	ERK2 →	+0.235	+2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by CLDN10 expression — UCEC

Explore this box plot interactively →