CLDN10

Across TCGA cell cohorts, CLDN10 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLDN10-associated genes across cancer lineages are SMIM23, LCE2A, and PTH. Each is linked with CLDN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN10-to-partner and partner-to-CLDN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by CLDN10-low versus CLDN10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN10→partner) and Y-score (partner→CLDN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	PTH →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.052	+4.887	.001	.009	3	1
SKIN	GALNTL5 →	+0.021	+4.415	<.001	.007	3	1
SKIN	CCR8 →	+0.024	+4.930	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SMIM23 by CLDN10 expression — BLOOD_Leukemia

Explore this box plot interactively →