CLCN7

Across TCGA patient cohorts, CLCN7 protein abundance is significantly associated with the RNA expression of many other genes, with 13,015 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLCN7-associated genes across cancer lineages are HK3, CTSZ, and SLC15A3. Each is linked with CLCN7 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLCN7-to-partner and partner-to-CLCN7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN7 versus HK3 in GBM, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN7→partner) and Y-score (partner→CLCN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HK3 →	+1.088	+0.218	.002	.003	3	6
GBM	CTSZ →	+0.701	+0.172	.004	.005	3	5
LSCC	SLC15A3 →	+0.664	+0.210	<.001	<.001	3	5
LSCC	TYROBP →	+0.543	+0.150	<.001	<.001	3	5
GBM	CTSD →	+0.820	+0.268	<.001	<.001	3	5
COAD	GLIPR2 →	+0.590	+0.236	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,015 associations by consensus.

CLCN7 vs HK3 — GBM

Explore this scatter interactively →