CLCN7

Across TCGA pan-cancer cohorts, CLCN7 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CLCN7 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CLCN7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLCN7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

KIRC, HNSC, and LUSC are the cancer types where CLCN7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.491	0.748	<.001	98	view →
HNSC	DFS	Median	III,IV	0.429	0.223	.001	96	view →
LUSC	DFS	Quartile	II,III,IV	0.427	0.842	.006	43	view →
LGG	OS	Quartile	All	0.852	0.945	.002	32	view →
BRCA	OS	Quartile	III,IV	0.969	0.838	.003	28	view →
LUAD	OS	Median	II,III,IV	0.591	0.341	.004	26	view →
ESCA	OS	Quartile	All	0.702	0.455	.011	23	view →
LIHC	OS	Quartile	All	0.659	0.820	.003	22	view →
SKCM	OS	Tertile	All	0.233	0.395	<.001	19	view →
PAAD	DFS	Tertile	II,III,IV	0.506	0.334	.023	19	view →
DLBC	DFS	Tertile	IV	1.000	0.287	.010	17	view →
SCLC	OS	Quartile	All	0.433	0.140	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CLCN7–KIRC (DFS)

Open the KIRC breakdown →