CLCN7

Across TCGA patient cohorts, CLCN7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN7-associated genes across cancer lineages are eIF4E, TFRC, and Caspase-7-cleavedD198. Each is linked with CLCN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN7-to-partner and partner-to-CLCN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CLCN7-low versus CLCN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN7→partner) and Y-score (partner→CLCN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+1.807	.031	.025	3	2
UCEC	TFRC →	+0.482	+1.874	.013	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.858	+1.926	<.001	.008	3	2
UCEC	ERK2 →	+0.190	+2.807	.007	.003	3	1
UCEC	Fibronectin →	-0.255	-1.847	.035	.008	3	1
UCEC	JNK2 →	+0.283	+1.817	<.001	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by CLCN7 expression — UCEC

Explore this box plot interactively →