CLCN7

Across TCGA cell cohorts, CLCN7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,972 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLCN7-associated GO terms across cancer lineages are Regulation of macroautophagy, Regulation of TOR signaling, and Pre-mRNA catabolic process. Each is linked with CLCN7 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLCN7-to-partner and partner-to-CLCN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by CLCN7-low versus CLCN7-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN7→partner) and Y-score (partner→CLCN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of macroautophagy →	+0.082	+1.481	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of TOR signaling →	+0.061	+1.678	<.001	<.001	3	16
BONE	Pre-mRNA catabolic process →	+0.217	+0.890	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.068	+1.050	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.062	+1.065	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.079	+1.269	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,972 associations by consensus.

Regulation of macroautophagy by CLCN7 expression — OESOPHAGUS

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