CLCN7

Across TCGA cell cohorts, CLCN7 mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN7-associated genes across cancer lineages are FAM205A, GHRHR, and C3orf85. Each is linked with CLCN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN7-to-partner and partner-to-CLCN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by CLCN7-low versus CLCN7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN7→partner) and Y-score (partner→CLCN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.018	+2.444	<.001	.001	3	2
BLOOD_Leukemia	GHRHR →	+0.474	+4.705	<.001	.003	3	1
BLOOD_Leukemia	C3orf85 →	+0.044	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.532	+3.087	.002	.006	3	1
LARGE_INTESTINE	CCDC134 →	+0.861	+3.131	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

FAM205A by CLCN7 expression — LARGE_INTESTINE

Explore this box plot interactively →