CLCN6

Across TCGA patient cohorts, CLCN6 mutation is significantly associated with the RNA expression of many other genes, with 2,196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN6-associated genes across cancer lineages are TRAJ19, PBK, and C17orf98. Each is linked with CLCN6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN6-to-partner and partner-to-CLCN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ19 grouped by CLCN6-low versus CLCN6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN6→partner) and Y-score (partner→CLCN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ19 →	+0.517	+2.781	<.001	.006	3	3
UCEC	PBK →	+0.692	+1.698	.001	<.001	3	3
UCEC	C17orf98 →	+0.316	+1.816	<.001	<.001	3	2
UCEC	CCL3 →	+0.637	+1.939	<.001	<.001	3	2
SKCM	MRGPRX6P →	+0.018	+3.054	<.001	.006	3	2
BRCA	RNU7-60P →	+0.709	+5.873	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,196 associations by consensus.

TRAJ19 by CLCN6 expression — COAD

Explore this box plot interactively →