CLCN5

Across TCGA pan-cancer cohorts, CLCN5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLCN5 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CLCN5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLCN5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where CLCN5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.424	.004	38	view →
HNSC	DFS	Median	All	0.607	0.893	.005	30	view →
PDAC	DFS	Tertile	II,III,IV	0.217	0.630	.009	8	view →
LUAD	OS	Median	III,IV	0.908	0.272	.013	6	view →
LSCC	OS	Tertile	All	1.000	0.690	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLCN5–CCRCC (DFS)

Open the CCRCC breakdown →