CLCN5

Across TCGA patient cohorts, CLCN5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,017 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLCN5-associated proteins across cancer lineages are HUWE1, TSR2, and RHOT1. Each is linked with CLCN5 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLCN5 versus HUWE1 in LSCC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HUWE1 →	+0.314	+0.717	<.001	<.001	3	6
OV	TSR2 →	+0.530	+1.114	<.001	<.001	3	4
LUAD	RHOT1 →	+0.235	+0.537	<.001	<.001	3	4
PDAC	SLC5A6 →	+0.685	+0.516	<.001	<.001	3	4
HNSC	CTPS2 →	+0.460	+0.733	<.001	<.001	3	4
LUAD	AKAP1_S592 →	+0.728	+0.467	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,017 associations by consensus.

CLCN5 vs HUWE1 — LSCC

Explore this scatter interactively →