CLCN5

Across TCGA patient cohorts, CLCN5 mutation is significantly associated with the RNA expression of many other genes, with 3,822 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN5-associated genes across cancer lineages are MIR208B, LETM1, and TSPAN17. Each is linked with CLCN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR208B grouped by CLCN5-low versus CLCN5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR208B →	+0.608	+3.384	<.001	.003	3	3
UCEC	LETM1 →	+0.338	+1.570	<.001	<.001	3	3
UCEC	TSPAN17 →	+0.247	+1.064	.003	.002	3	3
SKCM	UBTFL2 →	+0.015	+3.147	<.001	.005	3	3
UCEC	CCDC134 →	+0.422	+2.617	<.001	<.001	3	3
UCEC	AKT1 →	+0.249	+1.439	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,822 associations by consensus.

MIR208B by CLCN5 expression — CESC

Explore this box plot interactively →