CLCN5

Across TCGA patient cohorts, CLCN5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN5-associated genes across cancer lineages are p62 Lck ligand, ASNS, and Notch1. Each is linked with CLCN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CLCN5-low versus CLCN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.222	+1.957	.005	<.001	3	3
UCEC	ASNS →	+0.254	+1.289	.004	.018	3	3
UCEC	Notch1 →	+0.088	+1.194	.011	.012	3	2
UCEC	ATM →	-0.334	-1.510	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.422	+1.039	.003	.008	3	2
UCEC	C-Raf →	+0.106	+0.947	.002	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

p62 Lck ligand by CLCN5 expression — UCEC

Explore this box plot interactively →