CLCN5

Across TCGA cell cohorts, CLCN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,417 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLCN5-associated GO terms across cancer lineages are Copper ion export, Subtelomeric heterochromatin formation, and Regulation of heterochromatin formation. Each is linked with CLCN5 in more than 14 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by CLCN5-low versus CLCN5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Copper ion export →	-0.182	-1.172	<.001	<.001	3	15
BONE	Subtelomeric heterochromatin formation →	+0.137	+0.987	.005	.004	3	12
BONE	Regulation of heterochromatin formation →	+0.121	+1.052	.002	<.001	3	11
BLOOD_Myeloma	Regulation of chromatin organization →	+0.089	+1.173	<.001	<.001	3	11
SOFT_TISSUE	Regulation of body fluid levels →	-0.088	-2.081	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.168	+1.600	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,417 associations by consensus.

Copper ion export by CLCN5 expression — BONE

Explore this box plot interactively →