CLCN5

Across TCGA cell cohorts, CLCN5 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLCN5-associated genes across cancer lineages are SLC36A2, SCGB1C1, and LRRC74A. Each is linked with CLCN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN5-to-partner and partner-to-CLCN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC36A2 grouped by CLCN5-low versus CLCN5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN5→partner) and Y-score (partner→CLCN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC36A2 →	+0.015	+4.551	<.001	.004	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.096	+4.539	<.001	.007	3	1
LUNG_NSCLC_LUAD	LRRC74A →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.012	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	IL22 →	+0.043	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.024	+5.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SLC36A2 by CLCN5 expression — BLOOD_Leukemia

Explore this box plot interactively →