CLCN4

Across TCGA cell cohorts, CLCN4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCN4-associated genes across cancer lineages are OR9A2, VN1R2, and OR14A16. Each is linked with CLCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCN4-to-partner and partner-to-CLCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by CLCN4-low versus CLCN4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN4→partner) and Y-score (partner→CLCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	IL26 →	+0.310	+2.793	.001	.002	3	1
LARGE_INTESTINE	IL17C →	+0.209	+3.337	.009	.004	3	1
LARGE_INTESTINE	BPIFC →	+0.202	+2.906	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR9A2 by CLCN4 expression — BLOOD_Lymphoma

Explore this box plot interactively →