CLCN3P1

Across TCGA patient cohorts, CLCN3P1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCN3P1-associated genes across cancer lineages are Akt, PDCD4, and Caspase-7-cleavedD198. Each is linked with CLCN3P1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCN3P1-to-partner and partner-to-CLCN3P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by CLCN3P1-low versus CLCN3P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCN3P1→partner) and Y-score (partner→CLCN3P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.198	-2.449	.041	.019	3	2
UCEC	PDCD4 →	-0.719	-2.906	<.001	.001	2	3
UCEC	Caspase-7-cleavedD198 →	+0.885	+3.604	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.091	-2.973	.032	.035	3	1
UCEC	EGFR_pY1068 →	-0.392	-4.000	<.001	<.001	3	1
UCEC	ERK2 →	+0.283	+2.222	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Akt by CLCN3P1 expression — UCEC

Explore this box plot interactively →