CLCN3P1

Across TCGA pan-cancer cohorts, CLCN3P1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CLCN3P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLCN3P1 RNA is repressed in tumor relative to normal tissue. In most cancer types CLCN3P1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where CLCN3P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCN3P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.252	<.001	11	view →
HNSC	All	III,IV	+0.313	<.001	8	view →
THCA	Male	All	−0.191	<.001	7	view →
BRCA	All	All	−0.313	<.001	6	view →
LUSC	All	All	+0.388	<.001	5	view →
KICH	All	All	−0.235	<.001	5	view →
LIHC	All	All	+0.062	.011	5	view →
KIRP	All	All	−0.133	.004	2	view →
LUAD	All	All	+0.109	.012	2	view →
PRAD	All	All	−0.077	.001	2	view →
CHOL	Male	All	+0.050	.025	2	view →
BLCA	Male	IV	−0.177	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CLCN3P1–KIRC

Open the KIRC breakdown →