CLCC1

Across TCGA pan-cancer cohorts, CLCC1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CLCC1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CLCC1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CLCC1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where CLCC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.605	<.001	11	view →
COAD	All	III,IV	−0.166	<.001	9	view →
PDAC	Male	All	−0.798	<.001	6	view →
HNSC	All	All	+0.164	.006	6	view →
LSCC	Male	All	−0.143	<.001	4	view →
LUAD	Female	II,III,IV	+0.229	.019	3	view →
PDAC	All	IV	+0.613	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 6 lineages.

CLCC1–CCRCC

Open the CCRCC breakdown →