CLCC1

Across TCGA patient cohorts, CLCC1 mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCC1-associated genes across cancer lineages are TRAJ22, TEX29, and WHAMM. Each is linked with CLCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCC1-to-partner and partner-to-CLCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ22 grouped by CLCC1-low versus CLCC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCC1→partner) and Y-score (partner→CLCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ22 →	+0.989	+3.011	<.001	.009	3	2
UCEC	TEX29 →	+0.716	+3.721	<.001	<.001	3	1
UCEC	WHAMM →	+0.668	+2.179	<.001	.009	3	1
UCEC	SFXN2 →	-0.509	-3.435	.008	.005	3	1
UCEC	PKN3 →	+0.650	+3.354	.003	.005	3	1
UCEC	CXCL5 →	-1.530	-2.796	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

TRAJ22 by CLCC1 expression — COAD

Explore this box plot interactively →