CLCA4

Across TCGA pan-cancer cohorts, CLCA4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CLCA4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CLCA4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CLCA4 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where CLCA4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCA4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.655	<.001	12	view →
HNSC	Female	All	−3.017	<.001	11	view →
LSCC	All	II,III,IV	+1.021	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CLCA4–COAD

Open the COAD breakdown →