CLCA4

Across TCGA pan-cancer cohorts, CLCA4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CLCA4 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CLCA4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLCA4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

KICH, KIRC, and SKCM are the cancer types where CLCA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	II,III,IV	0.053	0.880	<.001	126	view →
KIRC	DFS	Quartile	All	0.501	0.656	.003	48	view →
SKCM	OS	Quartile	All	0.794	0.906	.001	37	view →
UCEC	DFS	Tertile	IV	0.192	0.728	.002	36	view →
HNSC	OS	Tertile	All	0.792	0.669	.003	34	view →
BRCA	DFS	Tertile	All	0.628	0.417	.001	31	view →
UVM	OS	Tertile	All	0.412	0.777	.019	27	view →
MESO	OS	Quartile	IV	0.129	0.679	<.001	21	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
COAD	DFS	Tertile	All	0.786	0.635	.007	18	view →
PAAD	DFS	Tertile	All	0.152	0.446	.010	16	view →
STAD	OS	Median	IV	0.647	0.241	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CLCA4–KICH (DFS)

Open the KICH breakdown →