CLCA4

Across TCGA patient cohorts, CLCA4 mutation is significantly associated with the RNA expression of many other genes, with 4,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCA4-associated genes across cancer lineages are CCNB2, SAAL1, and FEN1. Each is linked with CLCA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLCA4-to-partner and partner-to-CLCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by CLCA4-low versus CLCA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA4→partner) and Y-score (partner→CLCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.547	+1.632	.001	<.001	3	4
UCEC	SAAL1 →	+0.381	+2.016	.001	<.001	3	4
UCEC	FEN1 →	+0.619	+1.664	<.001	<.001	3	4
UCEC	PGAM1 →	+0.701	+2.828	<.001	<.001	3	4
UCEC	HASPIN →	+0.734	+1.830	<.001	<.001	3	4
UCEC	MSANTD3 →	+0.467	+1.642	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,789 associations by consensus.

CCNB2 by CLCA4 expression — UCEC

Explore this box plot interactively →