CLCA4

Across TCGA patient cohorts, CLCA4 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCA4-associated genes across cancer lineages are Cyclin-B1, p70-S6K, and FOXO3a_pS318_S321. Each is linked with CLCA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLCA4-to-partner and partner-to-CLCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CLCA4-low versus CLCA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA4→partner) and Y-score (partner→CLCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.648	+2.222	.001	.010	3	3
STAD	p70-S6K →	+0.266	+2.828	.044	.033	3	2
LUAD	FOXO3a_pS318_S321 →	-0.106	-2.983	.013	.034	3	2
LUAD	GSK3-a-b →	+0.139	+1.700	.034	.043	3	2
LUAD	PCNA →	+0.175	+2.334	.011	.018	3	2
LUAD	4E-BP1_pS65 →	+0.175	+1.887	.001	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-B1 by CLCA4 expression — LUAD

Explore this box plot interactively →