CLCA4

Across TCGA cell cohorts, CLCA4 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCA4-associated genes across cancer lineages are OR2A14, TPD52L3, and KRT71. Each is linked with CLCA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCA4-to-partner and partner-to-CLCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A14 grouped by CLCA4-low versus CLCA4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA4→partner) and Y-score (partner→CLCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR2A14 →	+0.032	+4.922	<.001	.009	3	2
LUNG_NSCLC_LUAD	TPD52L3 →	+0.263	+4.266	<.001	.004	3	2
SOFT_TISSUE	KRT71 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	KIR3DL1 →	+0.013	+5.977	<.001	.001	3	1
SOFT_TISSUE	DTHD1 →	+0.006	+4.930	<.001	.008	3	1
SOFT_TISSUE	SLC22A6 →	+0.025	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

OR2A14 by CLCA4 expression — BLOOD_Leukemia

Explore this box plot interactively →