CLCA4-AS1

Across TCGA pan-cancer cohorts, CLCA4-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CLCA4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLCA4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CLCA4-AS1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and BRCA are the cancer types where CLCA4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCA4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.861	<.001	12	view →
COAD	All	II,III,IV	−0.775	<.001	12	view →
BRCA	All	II,III,IV	−0.529	<.001	6	view →
KICH	Male	II,III,IV	−0.073	.004	6	view →
LUSC	All	All	+0.301	<.001	5	view →
UCEC	All	All	+0.256	<.001	4	view →
LUAD	All	All	+0.215	<.001	3	view →
READ	All	All	−1.266	.002	2	view →
PRAD	All	All	−0.319	<.001	2	view →
THCA	All	All	+0.055	.033	2	view →
KIRC	All	All	+0.028	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CLCA4-AS1–HNSC

Open the HNSC breakdown →