CLCA1

Across TCGA patient cohorts, CLCA1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCA1-associated genes across cancer lineages are VHL, p90 RSK, and Rad50. Each is linked with CLCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCA1-to-partner and partner-to-CLCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CLCA1-low versus CLCA1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA1→partner) and Y-score (partner→CLCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	VHL →	-1.245	-2.990	.005	.036	3	2
SKCM	p90 RSK →	+0.340	+2.321	<.001	.032	3	2
UCEC	Rad50 →	-0.197	-1.584	.015	.009	3	2
UCEC	ASNS →	+0.565	+1.874	<.001	.002	3	2
UCEC	C-Raf →	+0.172	+1.584	<.001	.009	3	2
LUSC	Beclin →	+0.153	+3.027	.033	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

VHL by CLCA1 expression — LUSC

Explore this box plot interactively →