CLCA1

Across TCGA pan-cancer cohorts, CLCA1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CLCA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CLCA1 RNA is repressed in tumor relative to normal tissue. In most cancer types CLCA1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and KICH are the cancer types where CLCA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLCA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−4.486	<.001	10	view →
READ	All	All	−4.116	.012	2	view →
KICH	Male	All	−0.014	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CLCA1–COAD

Open the COAD breakdown →