CLCA1

Across TCGA cell cohorts, CLCA1 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLCA1-associated genes across cancer lineages are OR2L8, CD93, and ZIM3. Each is linked with CLCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCA1-to-partner and partner-to-CLCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by CLCA1-low versus CLCA1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCA1→partner) and Y-score (partner→CLCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2L8 →	+0.021	+4.369	<.001	.008	3	2
LARGE_INTESTINE	CD93 →	+0.042	+2.157	.001	.005	3	2
SOFT_TISSUE	ZIM3 →	+0.014	+5.515	<.001	<.001	3	1
SOFT_TISSUE	OR2M5 →	+0.014	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR51I1 →	+0.486	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR13H1 →	+0.100	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

OR2L8 by CLCA1 expression — SOFT_TISSUE

Explore this box plot interactively →