CLC

Across TCGA patient cohorts, CLC mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLC-associated genes across cancer lineages are pDC and Mast cells. Each is linked with CLC in more than 1 cancer types. Because this analysis shows association rather than direction, both CLC-to-partner and partner-to-CLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by CLC-low versus CLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLC→partner) and Y-score (partner→CLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.093	+2.818	.001	.037	2	1
UCEC	Mast cells →	+0.019	+2.850	.045	.035	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

pDC by CLC expression — UCEC

Explore this box plot interactively →