CLC

Across TCGA pan-cancer cohorts, CLC RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CLC’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CLC RNA is repressed in tumor relative to normal tissue. In most cancer types CLC is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, BRCA, and LUAD are the cancer types where CLC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.954	<.001	4	view →
BRCA	All	All	−0.120	.007	4	view →
LUAD	All	II,III,IV	−0.940	.009	3	view →
LIHC	Male	All	−0.180	<.001	3	view →
PRAD	All	All	−0.302	.013	2	view →
HNSC	Female	All	+0.520	.025	1	view →
KICH	All	All	−0.189	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CLC–LUSC

Open the LUSC breakdown →