CLC

Across TCGA cell cohorts, CLC RNA expression is significantly associated with the go_rna of many other GO terms, with 760 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLC-associated GO terms across cancer lineages are Multivesicular body sorting pathway, Response to salt, and Endosome transport via multivesicular body sorting pathway. Each is linked with CLC in more than 4 cancer types. Because this analysis shows association rather than direction, both CLC-to-partner and partner-to-CLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Multivesicular body sorting pathway grouped by CLC-low versus CLC-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLC→partner) and Y-score (partner→CLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Multivesicular body sorting pathway →	+0.041	+0.939	<.001	.009	3	5
BLOOD_Leukemia	Response to salt →	+0.068	+1.208	.005	.006	2	4
BLOOD_Leukemia	Endosome transport via multivesicular body sorting pathway →	+0.080	+1.388	<.001	.003	3	3
BLOOD_Leukemia	Response to misfolded protein →	+0.067	+1.906	<.001	.002	3	3
LUNG_NSCLC_LUAD	Proteasomal ubiquitin-independent protein catabolic process →	+0.045	+0.038	.006	<.001	3	3
LUNG_NSCLC_LUAD	miRNA metabolic process →	+0.042	+0.032	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

Multivesicular body sorting pathway by CLC expression — BLOOD_Leukemia

Explore this box plot interactively →