Across TCGA pan-cancer cohorts, CKMT1A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CKMT1A data layer compared with 20 for mass-spec protein.
The strongest signal is observed in rectum adenocarcinoma (READ), where higher CKMT1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CKMT1A expression acts as an unfavorable survival marker.
READ, LUAD, and BLCA are the cancer types where CKMT1A Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.