Across TCGA patient cohorts, CKMT1A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKMT1A-associated genes across cancer lineages are EGFR_pY1068, EGFR, and GAPDH. Each is linked with CKMT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CKMT1A-to-partner and partner-to-CKMT1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKMT1A→partner) and Y-score (partner→CKMT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.285	-3.169	.023	.019	3	2
UCEC	EGFR →	-0.250	-3.000	.001	.036	3	1
UCEC	GAPDH →	+0.560	+2.321	.037	.035	3	1
UCEC	Heregulin →	-0.193	-3.308	.001	.009	3	1
UCEC	MSH2 →	-0.416	-3.160	<.001	.019	3	1
UCEC	MSH6 →	-0.431	-2.321	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

CKMT1A survival (RNA) · tumor vs normal (RNA) · all CKMT1A data types