Across TCGA patient cohorts, CKLF mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CKLF-associated genes across cancer lineages are UBTFL3, MIR764, and MIR4307. Each is linked with CKLF in more than 1 cancer types. Because this analysis shows association rather than direction, both CKLF-to-partner and partner-to-CKLF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKLF→partner) and Y-score (partner→CKLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBTFL3 →	+0.079	+7.954	<.001	.008	3	1
HNSC	MIR764 →	+0.578	+7.954	<.001	.008	3	1
HNSC	MIR4307 →	+0.582	+7.954	<.001	.008	3	1
SKCM	RNU6-543P →	+0.353	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

CKLF survival (RNA) · tumor vs normal (RNA) · all CKLF data types