CKB

Across TCGA patient cohorts, CKB protein abundance is significantly associated with the RNA expression of many other genes, with 8,686 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CKB-associated genes across cancer lineages are NOVA1, JAM2, and CAVIN2. Each is linked with CKB in more than 4 cancer types. Because this analysis shows association rather than direction, both CKB-to-partner and partner-to-CKB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CKB versus NOVA1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKB→partner) and Y-score (partner→CKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NOVA1 →	+1.109	+0.500	<.001	<.001	3	5
UCEC	JAM2 →	+0.807	+0.667	<.001	<.001	3	5
BRCA	CAVIN2 →	+1.090	+0.706	<.001	.002	3	5
GBM	MTURN →	+1.106	+0.359	.004	.007	3	5
GBM	CCDC71L →	-1.031	-0.347	<.001	<.001	3	4
LSCC	GLA →	-0.456	-0.749	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,686 associations by consensus.

CKB vs NOVA1 — GBM

Explore this scatter interactively →