CKB

Across TCGA cell cohorts, CKB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,327 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CKB-associated GO terms across cancer lineages are Phosphagen biosynthetic process, Phosphocreatine biosynthetic process, and Phosphocreatine metabolic process. Each is linked with CKB in more than 18 cancer types. Because this analysis shows association rather than direction, both CKB-to-partner and partner-to-CKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphagen biosynthetic process grouped by CKB-low versus CKB-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CKB→partner) and Y-score (partner→CKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Phosphagen biosynthetic process →	+1.495	+2.657	<.001	<.001	3	19
KIDNEY	Phosphocreatine biosynthetic process →	+1.495	+2.657	<.001	<.001	3	19
KIDNEY	Phosphocreatine metabolic process →	+1.495	+2.657	<.001	<.001	3	19
OVARY	Ribonucleoside triphosphate biosynthetic process →	+0.079	+1.829	.002	.004	2	12
OVARY	Adaptive thermogenesis →	+0.110	+2.198	.005	.002	3	10
SOFT_TISSUE	Granzyme-mediated apoptotic signaling pathway →	+0.108	+1.730	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,327 associations by consensus.

Phosphagen biosynthetic process by CKB expression — KIDNEY

Explore this box plot interactively →