CKAP2L

Across TCGA patient cohorts, CKAP2L mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CKAP2L-associated genes across cancer lineages are EGFR_pY1068, Annexin-1, and ATM. Each is linked with CKAP2L in more than 1 cancer types. Because this analysis shows association rather than direction, both CKAP2L-to-partner and partner-to-CKAP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CKAP2L-low versus CKAP2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CKAP2L→partner) and Y-score (partner→CKAP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-2.584	.019	.011	3	1
UCEC	Annexin-1 →	+0.694	+3.019	.004	.019	3	1
UCEC	ATM →	-0.533	-3.156	.011	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+1.235	+3.479	<.001	.002	3	1
UCEC	Caspase-8 →	-0.260	-3.143	.026	.018	3	1
UCEC	Chk2_pT68 →	-0.171	-2.990	.048	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by CKAP2L expression — UCEC

Explore this box plot interactively →