CKAP2L

Across TCGA pan-cancer cohorts, CKAP2L RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CKAP2L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CKAP2L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CKAP2L is over-expressed in tumor.

HNSC, BLCA, and LUAD are the cancer types where CKAP2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CKAP2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.011	<.001	12	view →
BLCA	Male	III,IV	+2.965	<.001	11	view →
LUAD	Male	III,IV	+2.670	<.001	11	view →
KIRP	All	III,IV	+1.389	<.001	11	view →
COAD	Male	IV	+1.378	<.001	11	view →
KIRC	Male	IV	+1.199	<.001	11	view →
LIHC	Female	II,III,IV	+1.558	<.001	9	view →
LUSC	Male	II,III,IV	+3.309	<.001	8	view →
UCEC	All	III,IV	+2.882	<.001	8	view →
STAD	Female	All	+2.331	<.001	8	view →
BRCA	All	III,IV	+2.315	<.001	6	view →
CHOL	Male	All	+2.718	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CKAP2L–HNSC

Open the HNSC breakdown →