CIZ1

Across TCGA patient cohorts, CIZ1 mutation is significantly associated with the RNA expression of many other genes, with 3,454 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIZ1-associated genes across cancer lineages are SNAI3, C5orf52, and LIN54. Each is linked with CIZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIZ1-to-partner and partner-to-CIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNAI3 grouped by CIZ1-low versus CIZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIZ1→partner) and Y-score (partner→CIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNAI3 →	+0.568	+3.331	.006	.005	3	2
COAD	C5orf52 →	-1.028	-3.459	.001	.005	3	2
UCEC	LIN54 →	+0.573	+2.818	<.001	<.001	3	2
COAD	SRGAP2B →	+0.227	+3.472	.003	.002	3	2
COAD	RNA5SP18 →	+0.873	+3.541	.005	.003	3	2
COAD	EP300-AS1 →	+0.980	+3.472	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,454 associations by consensus.

SNAI3 by CIZ1 expression — COAD

Explore this box plot interactively →