CICP21

Across TCGA pan-cancer cohorts, CICP21 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CICP21 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CICP21 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CICP21 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, LUSC, and UCEC are the cancer types where CICP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.804	0.655	.002	69	view →
LUSC	OS	Tertile	III,IV	0.117	0.717	.004	36	view →
UCEC	DFS	Tertile	All	0.814	0.909	.001	30	view →
OV	OS	Tertile	IV	0.778	0.533	.015	28	view →
KIRC	DFS	Tertile	III,IV	0.560	0.678	.021	25	view →
MESO	DFS	Quartile	III,IV	0.099	0.436	.005	21	view →
THYM	DFS	Tertile	All	1.000	0.697	.015	15	view →
UCS	DFS	Tertile	III,IV	1.000	0.222	.046	12	view →
ACC	OS	Tertile	All	0.299	0.683	.035	12	view →
CHOL	OS	Tertile	II,III,IV	0.201	0.700	.036	9	view →
STAD	DFS	Tertile	IV	0.097	0.412	.008	9	view →
PCPG	OS	Tertile	All	0.944	1.000	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CICP21–HNSC (DFS)

Open the HNSC breakdown →