CIBAR2

Across TCGA cell cohorts, CIBAR2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CIBAR2-associated genes across cancer lineages are USP17L11, USP17L17, and USP17L20. Each is linked with CIBAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIBAR2-to-partner and partner-to-CIBAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L11 grouped by CIBAR2-low versus CIBAR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIBAR2→partner) and Y-score (partner→CIBAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L11 →	+0.016	+5.415	<.001	.004	3	1
SKIN	USP17L17 →	+0.013	+6.022	<.001	.001	3	1
SKIN	USP17L20 →	+0.016	+5.415	<.001	.004	3	1
SKIN	USP17L18 →	+0.016	+5.415	<.001	.004	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

USP17L11 by CIBAR2 expression — SKIN

Explore this box plot interactively →