CIB3

Across TCGA cell cohorts, CIB3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CIB3-associated genes across cancer lineages are KLHL34, OOSP4A, and USP26. Each is linked with CIB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIB3-to-partner and partner-to-CIB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL34 grouped by CIB3-low versus CIB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIB3→partner) and Y-score (partner→CIB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL34 →	+0.117	+3.793	<.001	.007	3	1
LARGE_INTESTINE	OOSP4A →	+0.133	+3.793	<.001	.007	3	1
BLOOD_Leukemia	USP26 →	+0.036	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KLHL34 by CIB3 expression — LARGE_INTESTINE

Explore this box plot interactively →