CIB3

Across TCGA pan-cancer cohorts, CIB3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CIB3 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CIB3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CIB3 expression acts as an unfavorable survival marker, although some lineages such as CESC and BRCA show a favorable association.

CESC, ACC, and KIRC are the cancer types where CIB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.955	0.800	<.001	86	view →
ACC	DFS	Quartile	All	0.176	0.555	<.001	46	view →
KIRC	OS	Quartile	All	0.507	0.667	.001	42	view →
LGG	DFS	Median	All	0.782	0.879	<.001	29	view →
KIRP	OS	Tertile	All	0.820	0.911	.007	25	view →
COAD	DFS	Tertile	IV	0.258	0.575	.003	23	view →
THCA	OS	Tertile	II,III,IV	0.952	0.992	.003	19	view →
PCPG	DFS	Tertile	All	0.836	0.942	.011	18	view →
KICH	OS	Tertile	All	0.801	0.972	.018	15	view →
BRCA	OS	Median	II,III,IV	0.969	0.945	.008	14	view →
STAD	DFS	Median	III,IV	0.463	0.186	.017	12	view →
BLCA	OS	Tertile	All	0.681	0.546	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CIB3–CESC (OS)

Open the CESC breakdown →