CIART

Across TCGA patient cohorts, CIART mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIART-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Notch1. Each is linked with CIART in more than 1 cancer types. Because this analysis shows association rather than direction, both CIART-to-partner and partner-to-CIART results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CIART-low versus CIART-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIART→partner) and Y-score (partner→CIART) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.271	-2.807	.013	.003	3	1
UCEC	Ku80 →	+0.322	+2.820	.001	.001	3	1
UCEC	Notch1 →	+0.186	+3.179	.002	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.615	-2.321	.001	.034	3	1
UCEC	p62 Lck ligand →	+0.435	+3.331	.002	.005	3	1
UCEC	PDCD4 →	-0.512	-2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by CIART expression — UCEC

Explore this box plot interactively →